In a small bowl, combine the soy sauce, lemon juice, garlic powder and liquid wood-smoke flavoring. Preheat broiler pan for 5 minutes. Coat pan with shortening spray. Place catfish on broiler pan and brush with mixture.
Broil 3 inches from heat for 4-6 minutes, basting occasionally until catfish flakes easily.
(When substituting whole catfish for fillets, follow the above instructions, broiling catfish 3 inches from heat for 3 minutes. Turn catfish over, brush with sauce, and continue basting occasionally for 3 minutes or until catfish flakes easily.)